Localização: Botton-Champalimaud Pancreatic Cancer Center
Entidade Empregadora: Fundação Champalimaud
Posição: Pós-Doutoramento
Início da Candidatura: 20 Maio. 2025
We are seeking a highly motivated and skilled Post-Doctoral Fellow to join our dynamic research team at the Botton-Champalimaud Pancreatic Cancer Centre. This prestigious center is dedicated to advancing pancreatic cancer research and treatment through innovative approaches and multidisciplinary collaboration. The successful candidate will contribute to cutting-edge research aimed at understanding the molecular, metabolic and immune mechanisms of pancreatic cancer progression and developing novel therapeutic strategies. Working within this state-of-the-art facility, you will have access to advanced technologies and a network of world-renowned experts in the field of pancreatic cancer. The successful candidate will work within the Cancer Systems laboratory led by Anguraj Sadanandam.
1. Design and conduct experiments to investigate pancreatic cancer biology, including tumor heterogeneity, tumor invasion and metastasis, tumor microenvironment, metabolism, and drug resistance mechanisms;
2. Develop and optimize in vitro and in vivo models of pancreatic cancer, including patient-derived organoids;
3. Utilize laser capture microdissection (LMD) and multiplex imaging system to study tumor classification, heterogeneity, and their interaction with surrounding tumor microenvironment (TME);
4. Analyze and interpret complex experimental data using advanced statistical and bioinformatic tools;
5. Present research findings at team meetings, conferences, and scientific symposia;
6. Prepare manuscripts for publication in peer-reviewed journals;
7. Collaborate with other researchers and clinicians within the Botton-Champalimaud Pancreatic Cancer Centre and external partners;
8. Mentor and supervise junior researchers and graduate students;
9. Contribute to grant writing and funding applications;
10. Participate in translational research initiatives to bridge laboratory findings with clinical applications;
11. Engage in knowledge exchange and public outreach activities to promote pancreatic cancer awareness and research;
12. Prepare Standard Operating Procedures (SOPs) for laboratory techniques and experimental protocols;
13. Contribute to the development and maintenance of quality management systems within the research facility.
- Directors of the Botton-Champalimaud Pancreatic Cancer Centre;
- Head of Laboratory;
- Health and Safety Officer;
- Laboratory Manager;
- Research Group Leaders;
- Advanced Technology Heads;
- Scientific researchers.
E-mail: [email protected]
Cancer Biology, Molecular Biology, Biochemistry, or a related field.
PhD or equivalent
- Problem solving;
- Flexibility;
- Attention to detail;
- Communication;
- Organization;
- Initiative.
1. Ph.D. in Cancer Biology, Molecular Biology, Biochemistry, or a related field;
2. Strong background in cancer research, preferably with experience in pancreatic cancer, pancreatic neuroendocrine cancer, RNA and immune biology and metabolism;
3. Expertise in molecular biology techniques, cell culture, and animal models;
4. Expertise in advanced imaging techniques (e.g., multiplex immunofluorescence, spatial profiling and analysis);
5. Excellent written and verbal communication skills;
6. Demonstrated ability to work independently and collaboratively in a multidisciplinary environment;
7. Track record of scientific publications in peer-reviewed journals;
8. Good level of English.
1. Experience with tissue processing and sectioning;
2. Familiarity with next-generation sequencing and multi-omics data analysis;
3. Experinece in metabolic data analysis;
4. Experience in data analysis, cell annotation software;
5. Knowledge of drug discovery and development processes;
6. Experience with grant writing and securing research funding.
All individuals are expected to be flexible in undertaking the duties and responsibilities attached to their job and may be asked to perform other duties which reasonably correspond to the general character of their job and their level of responsibility.
All individuals are expected to maintain personal and professional development to meet the changing demands of the job and participate in appropriate learning and development activities.
- Competitive salary and benefits package;
- Opportunity for professional development and growth within a cutting-edge research environment;
- Contribute to impactful research that makes a difference in the field of pathology.
- Professor Peter Bailey (Director of Translational Research);
- Professor Anguraj Sadanandam (Laboratory Head/Affiliated Scientist);
- Professor Vincenzo Corbo (Laboratory Head).
Line Manager - Professor Anguraj Sadanandam
Candidates must send a single PDF file named "FirstNameLastName_PRT_BCPCC" to "[email protected]" containing:
(i) A letter of motivation (max. 2 pages), highlighting your suitability for the role, salary expectations and notice period;
(ii) a CV (max. 2 pages);
(ii) Names and contact information for at least 2 references. If you do not wish that we contact current or past employers, please state so and why in your letter of motivation.
Evaluation and Selection Criteria. All CVs and motivation letters will be reviewed by the selection committee. Reference letters will be requested from shortlisted candidates, and those candidates deemed particularly well suited for the position will be invited for an interview.
one month from the date of publication of the advertisement.
12 months, renewable.
The Botton-Champalimaud Pancreatic Cancer Centre is a state-of-the-art facility comprising research laboratories, a day hospital, a surgical centre, as well as inpatient and intensive care facilities. The mission of the Botton-Champalimaud Pancreatic Cancer Centre is to develop new and effective treatments for pancreatic cancer. To accomplish this goal a multidisciplinary team of surgeons, clinicians, clinical trials specialists, cancer scientists, genomics experts and computational biologists work together to deliver world-leading outcomes for patients with pancreatic cancer.
The Botton-Champalimaud Pancreatic Cancer Centre is also closely integrated with the Champalimaud Centre for the Unknown. Members of the Champalimaud Research Programme (CR) and the Champalimaud Clinical Centre (CCC), work together to investigate fundamental biological processes and search for effective solutions to alleviate the burden of oncological, neurological and mental diseases, while providing state-of-the-art care to the patients of the CCC. With 479 members, including group leaders, postdocs, PhD and MSc students, research technicians and highly specialised research staff, the CR community encompasses 39 nationalities. Within the Lisbon Ocean Campus, CF will expand its research, technological development, innovation, and clinical practice in the digital therapeutics field.
In line with our community guidelines and Equality, Diversity and Inclusion policy and Gender Equality Plan, no candidate may be privileged, favoured, prejudiced or deprived of any right or excluded from any duty on the basis of age, sex, gender identity, sexual orientation, race/ethnicity, disability, chronic illness, language, nationality, territory of origin, family status (marital, pregnancy and maternity, having or not having dependents), socioeconomic situation, education, religion, political or ideological beliefs, trade union membership, or on any other grounds which are irrelevant to decision-making.
Consistent with our personnel policies, your first six (6) months will be probationary. This probationary period is an important time for you to understand your position and see if you and the Department are satisfied with expectations. At approximately the six (6) month mark, you will meet with your supervisor to review your performance and evaluate the job match.
HR Excellence in Research
The present call has the sole purpose of filling the indicated research position. This call may be cancelled at any time on or before the jury’s evaluation of all eligible candidates and the recruitment process shall be concluded on the day of the full execution of the contract between the Champalimaud Foundation and the selected candidate.
